Ednra

Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3 (By similarity).

Bgee allows to automatically compare gene expression patterns between species, by referencing expression data on anatomical ontologies, and designing homology relationships between them. Ednra tm1b(EUCOMM)Hmgu: Reporter-tagged deletion allele (post-Cre) Mice Ednra tm1a(EUCOMM)Hmgu: KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells: Ednra tm1(NCOM)Mfgc EDNRA (endothelin A receptor) is a 427 amino acid (aa) protein of the rhodopsin-like 7-transmembrane receptor family. It can be variably modified by N-linked glycoproteins, phosphorylation and palmitoylation. It binds endothelins ET-1 and ET-2 preferentially, while EDNRB binds all three forms equally. The results obtained in the present study about the link of rs5370 (EDN1 gene) and rs5335 (EDNRA gene) polymorphisms with LAS showed that in a Ukrainian population, only the rs5370 locus is associated with the development of the mentioned disease. Endothelin A Receptor (ETAR) Cite this entry as: (2012) EDNRA.

24.07.2021

ednra_human

This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. The following transcription factors affect gene expression: p53; CREB; AP-1; c-Jun; deltaCREB; C/EBPalpha; c-Fos; Tissue specificity: Isoform 1, isoform 3 and isoform 4 are expressed in a variety of tissues, with highest levels in the aorta and cerebellum, followed by lung, atrium and cerebral cortex, lower levels in the placenta, kidney, adrenal gland, duodenum, colon, ventricle and liver but Functional Associations. EDNRA has 6,015 functional associations with biological entities spanning 8 categories (molecular profile, organism, functional term, phrase or reference, chemical, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 85 datasets. EDNRA-201 ENSP00000315011 ENST00000324300: P25101 [Direct mapping] Endothelin-1 receptor .

EDNRA (Endothelin Receptor Type A) is a Protein Coding gene. Diseases associated with EDNRA include Mandibulofacial Dysostosis With Alopecia and Migraine With Or Without Aura 1 . Among its related pathways are RET signaling and Signaling by GPCR .

EDNRA gene expression in Bgee. Bgee allows to automatically compare gene expression patterns between species, by referencing expression data on anatomical ontologies, and designing homology relationships between them. Ednra tm1b(EUCOMM)Hmgu: Reporter-tagged deletion allele (post-Cre) Mice Ednra tm1a(EUCOMM)Hmgu: KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells: Ednra tm1(NCOM)Mfgc EDNRA (endothelin A receptor) is a 427 amino acid (aa) protein of the rhodopsin-like 7-transmembrane receptor family.

EDNRA DrugBank Gene Name P25101 UniProt Accession 1909 Entrez Gene Id Gene Info: Publications: Martin et al., 2000, Differential effects of the mixed ET(A)/ET(B)-receptor antagonist bosentan on endothelin-induced bronchoconstriction, vasoconstriction and prostacyclin release., Naunyn Schmiedebergs Arch. Pharmacol.

Gene: EDNRA. GWAS; Genes; EDNRA. EDNRA. Gene information.

Find diseases associated with this biological target and compounds tested against it in bioassay experiments. This gene encodes the receptor for endothelin-1, a peptide that plays a role in potent and long-lasting vasoconstriction. This receptor associates with guanine-nucleotide-binding (G) proteins, and this coupling activates a phosphatidylinositol-calcium second messenger system. EDNRA Antibodies This gene encodes the receptor for endothelin-1, a peptide that plays a role in potent and long-lasting vasoconstriction. This receptor associates with guanine-nucleotide-binding (G) proteins, and this coupling activates a phosphatidylinositol-calcium second messenger system. Receptor for endothelin-1.

The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3 (By similarity). Browse information about EDNRA (ENSG00000151617) covering related drugs, protein structure, pathways, genetic associations, orthologs, RNA expression and cancer biomarkers. ednra_human

The seventh letter of the Greek alphabet. See Table at alphabet. Edn1-Ednra signalling is essential for functional regulation of the heart by sympathetic nerves. Smooth muscle ETA is important for normal vascular, mandibular and thymic development and is involved in the maintenance of arterial pressure under physiological conditions. EDNRA (Endothelin receptor type A) active file. Summary of EDNRA.

endothelin receptor type A [Source: NCBI 10 items per page, 20 items per page, 50 items per page, 100 items per page, 200 items per page. Items: 1 to 1 of 1. EDNRA: endothelin receptor type A. Gene. Immunohistochemistry and western blotting showed the expression of Ednra and the activation of NOD-like receptor pyrin domain containing 3 (NLRP3) 21 Oct 2003 These encoded the endothelin receptor type A (EDNRA), which transduces most of the vasoconstrictive properties of endothelin‐1, protein EDNRA (endothelin receptor type A), also referred as ETA, is a member of the receptor group for endothelin-1 belonging to the G protein-coupled receptor in 25 products Compare Anti-EDNRA Flow Cytometry Antibody Products from leading suppliers on Biocompare. View specifications, prices, citations, reviews, and Anti-Ednra (ET-A) antibody is validated on mouse tissue and recommended for immunofluorescence labeling, IHC, or western blot. Ednra signaling during CNC cell development appears conserved among vertebrates, as pharmacological antagonism of Ednra in the rat (Spence et al., 1999) or Our findings highlight the importance of finely tuned regulation of EDNRA signaling during human craniofacial development and suggest that modification of Western blot analysis using an EDNRA polyclonal antibody (Product peptide between 125-154 amino acids from the central region of human EDNRA.

Validated: WB, ICC/IF, IHC, IHC-P, IP. Tested Reactivity: Mouse. Rabbit Polyclonal Antibody for ETAR Antibody (EDNRA) detection.tested for WB, IF, ELISA in Human, Mouse, Rat. Datasheet 1 Nov 2019 It is believed that both EDNRA and EDNRB are coupled to Gq (and Gs/Gi) proteins, thus their activation can trigger multiple downstream signaling EDNRA and EDNRB (endothelin A and B receptors, respectively) are members of the rhodopsin-like 7-transmembrane receptor family. EDNRA binds endothelins Gene: EDNRA ENSCHIG00000019737 . twitter logo Twitter facebook logo Facebook email logo Email.

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Description: Homo sapiens endothelin receptor type A (EDNRA), transcript variant 4, non-coding RNA. (from RefSeq NR_045958) RefSeq Summary (NM_001957): This gene encodes the receptor for endothelin-1, a peptide that plays a role in potent and long-lasting vasoconstriction. This receptor associates with guanine-nucleotide-binding (G) proteins, and this coupling activates a …

Ednra, encoding Endothelin receptor A (ETA)-the target of Endothelin 1 (ET-1)-was significantly increased in Systemic Capillary Leak Syndrome blood-outgrowth endothelial cells compared to healthy controls.